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Summary: Calorie restriction is often reported to lower IGF-1 levels, but studies have found this to be more the case in rodents than humans

doi: 10.1016/j.ymgme.2004.04.005

Their papers abstract could be interpreted to suggest that the B12 content in multivitamins was decreased by storage time, light exposure, temperature, and vitamin C

Based on experience in the treatment of other fibrotic diseases, there are a variety of alternative intervention strategies that target the mechanisms in the fibrotic transformation of fibroblast into myofibroblasts such as small molecules or compounds that are currently in clinical trials demonstrating good anti-fibrotic properties (250)