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In addition, since some studies have also recorded failure in antioxidant supplementation efficacy, optimal design of clinical trials in terms of targeted delivery of antioxidants, clinical pathology and concentration dependent dosage schedule is needed to go ahead in the knowledge and future application of this kind of treatment in CIPN (Kamat et al., 2008)

Diagnosis and treatment Thrombocytopenia can be diagnosed through a complete blood count examination, identifying the number of platelets

Furthermore, the identification and rectification of nutritional deficiencies through suitable interventions, including nutritional support and/or supplementation with fat-soluble vitamins, vitamin B12, iron, and folate, is of paramount importance [4]

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