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Multiple coenzymes are required in some pathways, for example, the synthesis of catecholamines from tyrosine requires tetrahydrobiopterin (BH4), pyridoxal phosphate (PLP, a derivative of vitamin B6), ascorbate (vitamin C) and the co-substrate S-adenosylmethionine (SAM) as the methyl group donor in the final methylation step from norepinephrine to epinephrine

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