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10.2337/db08-1637 22 GravdalK.KirsteK

At the molecular level, researchers conducted a multiomics data mining study and found that multiple selenoproteins are lowly expressed in thyroid cancer (89), which is associated with reduced selenoproteins content and activity due to Se deficiency and is consistent with the results of several previous studies (90, 91).GPx3 is known to be the only member of the GPx family that can be secreted into the plasma and therefore it can play an important role in extracellular oxidative stress (92), which enhances the antioxidant defense of cells via a blockage of redox DNA destruction, thus reducing as well a reduction in the abundance of damaged cells (93)

After overnight TEV digestion at 4 C, the GST elution was then loaded on a Superdex 75 Increased 10/300 GL column (Cytiva) preequilibrated with wash buffer

Protein sources like eggs and lean meats