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ChiuYEHavensPLSiegelDHAliOWangTHollandKEet al

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However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria