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Because L-Citrulline largely bypasses first-pass liver metabolism, it raises plasma L-Arginine levels more efficiently than direct L-Arginine supplementation, gram for gram - a pharmacokinetic advantage that's driven by growing research interest in this amino acid specifically

It has been shown to facilitate long-chain fatty acid entry into cellular mitochondria, thereby delivering substrate for oxidation and subsequent energy production

Administering AOD-9604 when these receptors are already occupied or downregulated produces suboptimal results regardless of dose