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Specifically, it regulates electric nicotine delivery systems (ENDS) such as: E-cigarettes E-cigars E-pipes Hookah pens Vape pens Vapes Vaporizers Here are several examples of FDA-regulated ENDS components and parts: E-liquids Atomizers Cartomizers and clearomizers Mouthpieces or drip tips Tank systems Certain batteries Here are some of the key requirements you should keep in mind: You should submit an ingredient list to the FDA You should report any harmful and potentially harmful constituents (HPHCs) to the FDA You should affix a health warning statement You should register your establishment with the FDA You should submit a Premarket Tobacco Product Application (PMTA) for new product types Ingredient list submission Importers and manufacturers of ENDS, including e-cigarettes, should submit an ingredient listing 90 days before selling their product