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The reduction in CBF and the diminished vasodilatory response of cerebral vessels to CO 2 , due to the accumulation of A, suggest compromised cerebrovascular reactivity examined by transcranial Doppler and the blood oxygenation level-dependent (BOLD) functional MRI (fMRI) [191,192,193]

In cultured hippocampal neurons, Dihexa treatment for 5 days induced a near 3-fold increase in the number of actin-enriched spines by 41 spines/50m for Dihexa vs

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